No, there's no way to do this.
Any option that did what you want would be extremely confusing because there would need to be a way to turn it off within the string literal syntax. There are other considerations (like storage size) to be aware of when choosing data types, so a setting like this could be very dangerous to put in play.
With regards to .NET applications that send parameterized T-SQL statements to SQL Server, the framework takes care of this for you because a .NET
String inherently supports Unicode and things were built using that assumption. This applies to ORM-type libraries as well if they're programmed well.
Consider the following code snippet:
IDbCommand cmd = connection.CreateCommand();
cmd.CommandText = @"SELECT * FROM sys.server_principals WHERE name = @name";
IDbDataParameter param = cmd.CreateParameter();
param.DbType = DbType.String;
param.ParameterName = "@name";
param.Value = "dbo";
IDataReader dr = cmd.ExecuteReader();
What actually gets sent to SQL Server is this (line break added for clarity):
exec sp_executesql N'SELECT * FROM sys.server_principals WHERE name = @name',
You can see that the framework automatically used a Unicode type for the parameter (the length of 3 is a separate discussion entirely...).
The places where you need to modify code are in situations where SQL queries are not parameterized (or are unparameterizable, i.e., DDL) -- in other words, queries that have parameters concatenated directly into the string, or contain string constants. See my answer here for an example of how to avoid SQL injection issues when using dynamic SQL.