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Without discounting anything stated in @Shanky's answer, it should be noted that the specific AppDomain being unloaded is in the [mssqlsystemresource] database. This is an internal database that stored built-in SQL Server functionality. Other built-in functionality resides in the [master] database. Even with the server-level configuration option of "CLR ...


To start with you have SQL Server 2012 patched to SP1. I would urge you, ASAP, patch SQL Server with SQL Server 2012 SP2 There has been some prominent memory related fix in SQl Server 2012 Sp2. Please read one of the KB Article documenting OOM error fix. If you look closely the fix is also for AppDomain 3181 () is marked for unload due to memory ...

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