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I have a client at my employer's company with 192GB RAM using 162GB Buffer Pool.

Here is what we did for the client

• InnoDB Tuning : I set the following options
• innodb_read_io_threads (maxed it to 64)
• innodb_write_io_threads (maxed it to 64)
• innodb_thread_concurrency = 0 (It's default now in MySQL 5.5/5.6)
• innodb_io_capacity (set it to IOPs of Disk, for this client, 20000 [2-0-0-0-0 not typo])
• innodb_buffer_pool_size=162G
• innodb_buffer_pool_instances=2 (Number of Physical Cores)
• OS Tuning (numactl --interleave=all)

If you forget numactl --interleave=all, the buffer pool experiences swapping.

Here are my past posts on tuning InnoDB

• Oct 22, 2012 : How large should be mysql innodb_buffer_pool_size?
• Jul 23, 2012 : How to get the most out of MySQL on a QuadCore machine with 16 GB of RAM?
• Jul 21, 2012 : InnoDB - High disk write I/O on ibdata1 file and ib_logfile0
• Sep 20, 2011 : Multi cores and MySQL Performance
• Sep 12, 2011 : Possible to make MySQL use more than one core?