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A version of JD Schmidt's answer, but without the awkwardness of an extra column:

CREATE TABLE foo (
  FieldA INT,
  FieldB INT
);

DELIMITER //
CREATE TRIGGER FieldABNotNull BEFORE INSERT ON foo
FOR EACH ROW BEGIN
  IF (NEW.FieldA IS NULL AND NEW.FieldB IS NULL) THEN
    SIGNAL SQLSTATE '45000' SET MESSAGE_TEXT = '\'FieldA\' and \'FieldB\' cannot both be null';
  END IF;
END//
DELIMITER ;

INSERT INTO foo (FieldA, FieldB) VALUES (NULL, 10); -- OK
INSERT INTO foo (FieldA, FieldB) VALUES (10, NULL); -- OK
INSERT INTO foo (FieldA, FieldB) VALUES (NULL, NULL); -- gives error