I'm using Percona Server 5.6.31 on RHEL 6. 64G RAM/16vCPU - VMware. Completely InnoDB. Database size is 300G. I have set Innodb_buffer_pool as 52G and innodb_buffer_pool_instances as default (8) and innodb_flush_method as O_DIRECT. Innodb_read_io_threads and write_io threads is set to 64. Memory utilization is most of the times is high above 90%. CPU utilization varies. Sometimes spikes. vm.swappiness is set to default (60). I have two queries: 1. What should be my value for innodb_buffer_pool_instances? Is it right or is a change required? 2. I read many articles suggesting that swappiness needs to be set to 1 or 0 or 10 for MySQL database servers. But I do not observe any swapping on the OS. Do I need to still swappiness to 0 or 1. Is it better to change the value on proactive basis or I should change only when it swaps? I can provide more info if required.